Retinol Binding Protein 4(RBP4)

RBP4 protein (Datasheet)

Description	RBP4 protein (21.9kD) with His-tag, cultured in vitro
Applications	Calibrator and quality control product
Catalog number	K5916
Source	Mammalian cell
Purity	>90% as analysized by SDS-PAGE
Buffer	1 x PBS，pH 7.4
Storage instructions	Store at - 80°C (– 112°F) for up to 3 years.
Sequence	AVVKVPLKKF KSIRETMKEK GLLGEFLRTH KYDPAWKYRF GDLSVTYEPM AYMDAAYFGE ISIGTPPQNF LVLFDTGSSN LWVPSVYCQS QACTSHSRFN PSESSTYSTN GQTFSLQYGS GSLTGFFGYD TLTVQSIQVP NQEFGLSENE PGTNFVYAQF DGIMGLAYPA LSVDEATTAM QGMVQEGALT SPVFSVYLSN QQGSSGGAVV FGGVDSSLYT GQIYWAPVTQ ELYWQIGIEE FLIGGQASGW CSEGCQAIVD TGTSLLTVPQ QYMSALLQAT GAQEDEYGQF LVNCNSIQNL PSLTFIINGV EFPLPPSSYI LSNNGYCTVG VEPTYLSSQN GQPLWILGDV FLRSYYSVYD LGNNRVGFAT AAHHHHHH
SDS-PAGE

Description

Retinol-binding protein 4 (RBP4), as a sole retinol transporter in blood, is secreted from adipocytes and liver. The essence of RBP4 is a small molecule combination protein with hydrophobic properties, which is one of many transgenic proteins with ability to transport fat-soluble vitamins. RBP4 has been a drug target for ophthalmology research due to its role in vision. It may also be involved in metabolic diseases.

Adipocyte-specific deletion of Gluts led to notable elevation of RBP4 causing systemic insulin resistance, and that reduction of RBP4 improved insulin resistance. It identifies an important role of RBP4 in regulating insulin action and RBP4 is recorded as an adipocyte-derived hormone. Thus, measurement of serum or plasma RBP4 is a useful method for understanding metabolic disorders.

Retinol Binding Protein 4(RBP4)

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